Research in the Cardoso lab focuses on the regulation of lung development, regeneration-repair and the role of developmental signaling in adult lung diseases. Ongoing studies aim to elucidate the origin of the tissue-specific stem cells of the lung, how they form and transition to differentiate into specific epithelial cell types. We are investigating the molecular and cellular events that control the organization and behavior of the stem cell compartment in human and mouse airways. We study how failure of these mechanisms leads to aberrant differentiation programs and their impact in the pathogenesis, progression and severity of pulmonary diseases. Lab projects concentrate on the mechanisms that control lung organogenesis, the establishment of cell fate in the fetal lung and the role of pathways, such as Notch, Hippo-Yap and retinoid in these processes.